Question

The major disadvantage of cosmids is

(a) inability to accept more than 40 - 50 kbp of DNA

(b) allow the packaging of DNA in phage in vitro

(c) also perpetuate in bacteria

(d) can produce a complete genome library of 10⁸

Answer 1

Answer is : (a) inability to accept more than 40 - 50 kbp of DNA

The major disadvantage of cosmids is their inability to accept more than 40 - 50 kbp of DNA. Cosmids are the vectors, which can accommodate DNA segments upto 45 kbp.