1. In 1966, Crick proposed Wobble hypothesis.
2. According to this hypothesis, in codonanticodon base pairing, the third base may not be complementary.
3. The third base of codon is called wobble base and this position is called wobble position.
4. This results in economy of t-RNA as anticodon of a t-RNA may bind with codon even when only first two bases are complementary.
5. For example, GUU, GUC, GUA and GUG codons code for amino acid Valine.
6. Degeneracy of genetic code means many codons can code for same amino acid.
7. Thus, the degeneracy of genetic code gets explained by Wobble hypothesis.
