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A relevant portion of `beta`-chain of haemoglobin of a normal human is given below :

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A relevant portion of `beta`-chain of haemoglobin of a normal human is given below :
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Due to mutation A , GAG mutates to GAA. Both GAG and GAA code for glutamic acid and hence there is no change in RBCs. Whereas GUG formed due to mutation B codes for valine and so the RBCs become sickle-shaped.
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