Question

Assertion A genetic probe is helpful in the detection of specific DNA sequence.
Reason Genetic probe is a radiolabelled cDNA, which has complementary base sequence, to DNA fragment which is to be detected.
A. Both Assertion and Reason are true and the Reason is correct explanation of the Assertion
B. Both Assertion and Reason are true but the Reason is not the correct explanation of the Assertion
C. Assertion is true, but the Reason is false
D. Assertion is false, but the Reason is true

Answer 1

Correct Answer - a
Probe are small nucleotide sequences used to detect the presence of complementary sequences in nucleic acid samples.
This is achieved by permitting the probes to base pair witht the sample nucleic acids and then identifying the samples that show base pairing with probes, i.e. hybridisation.
The probes an either be labelled with (i) radioactivity, e.g. `P^(32)` or (ii) with non-radioactive labels, e.g. biotin, digoxigenin, etc.