ADA enzyme is crucial for the immune system to function Deletion of the gens for adenosine deaminase results into ADA deficiency.
In some children. ADA deficiency can be cured by b one-marrow transplantation while in others it can be treated b y enzyme replacement therapy. in which functional ADA is given to others it can be treated b y enzyme replacement therapy. in which functional ADA is given to the patient by injection. but the problem with both of these approaches is that they are not completely curative.
It may recurrent in nature as in the process of gene therapy. lymphocytes used are found not to be immortal in nature and the patient requires a periodic infusion of such genetically engineered lymphocytes.
For permanent cure gene isolated from the bone-marrow cells producing ADA is introduced into cells at early embryonic stages.
