1. The conversion of pyruvic acid to acetyl CoA is an oxidative decarboxylation reaction.
2. It is catalyzed by a multienzyme complex-pyruvate dehydrogenase complex (PDH). This enzyme is present in mitochondria of eukaryotes and cytosol of prokaryotes.
3. This reaction is called as ‘connecting link’ reaction between glycolysis and Krebs cycle.
