Question

In the program DIALIGN, pairs of sequences are aligned to locate aligned regions that do not include gaps, much like continuous diagonals in a dot matrix plot.

(a) True

(b) False

The question was posed to me in final exam.

I want to ask this question from Iterative Methods of Multiple Sequence Alignment topic in portion Multiple Sequence Alignment of Bioinformatics

Answer 1

Correct choice is (a) True

Explanation: The program DIALIGN finds an alignment by a different iterative method. Pairs of sequences are aligned to locate aligned regions that do not include gaps, much like continuous diagonals in a dot matrix plot. Diagonals of various lengths are identified. A consistent collection of weighted diagonals that provides an alignment which is a maximum sum of weights is then found.