Question

The Chou–Fasman algorithm determines the propensity or intrinsic tendency of each residue to be in the helix, strand, and β-turn conformation using observed frequencies found in protein crystal structures.

(a) True

(b) False

I got this question in exam.

My doubt stems from Protein Secondary Structure Prediction  for Globular Proteins in portion Secondary Structure Prediction of Bioinformatics

Answer 1

Correct choice is (a) True

The best I can explain: It determines the propensity or intrinsic tendency of each residue using observed frequencies found in protein crystal structures (conformational values for coils are not considered). For example, it is known that alanine, glutamic acid, and methionine are commonly found in α-helices, whereas glycine and proline are much less likely to be found in such structures.