Question

The alignment score is the sum of substitution scores and gap penalties in this type of algorithm.

(a) True

(b) False

I have been asked this question in quiz.

The origin of the question is Needleman topic in portion Multiple Sequence Alignment of Bioinformatics

Answer 1

Right choice is (a) True

Easiest explanation: Use of +1 as a reward for a match, -1 as the penalty for a mismatch, and ignoring gaps is the scoring scheme of this type of method. Hence, the alignment score is the sum of substitution scores and gap penalties in this type of algorithm.