Question

Antibody fragments lack fc domain.

(a) True

(b) False

I have been asked this question in examination.

I want to ask this question from Products of Animal Cell Cultures topic in chapter Bioprocess Considerations in Using Animal Cell Cultures of Bioprocess Engineering

Answer 1

The correct answer is (a) True

Easiest explanation: There are a range of applications in which Fc mediated effects are not required and are even undesirable. A common solution for applications where the antibody is only being used to block a signalling molecule or receptor is the use of antibody fragments that lack the Fc domain. This also helps to reduce the other main failure of therapeutic antibodies, namely the lack of delivery, which is especially true for anti-cancer antibodies.