Correct Answer - Option 3 : upon
The correct answer is upon.
- Upon is a preposition which means the same as on.
- Sometimes it also means immediately after.
- For example, Upon further review, his suspension was retracted.
- But here, upon is used after the verb eating instead of on.
From above given points, we can infer that the complete sentence is worrying is eating upon his heart.
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Into: It's a preposition that describes the position of within or inside.
- For example:
- Please help me to sort these files into different folders.
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At: A preposition to show an exact position.
- For example:
- She left the letter at the countertop..
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In: As a preposition it points out the location
- For example:
- We can organize the meeting in the garden.