Question

Which technique among the following, is most appropriate in separation of a mixture of 100 mg of p-nitrophenol and picric acid ?

(A) Steam distillation

(B) 2-5 ft long column of silica gel

(C) Sublimation

(D) Preparative TLC (Thin Layer Chromatography)

Answer 1

Correct option is (D) Preparative TLC (Thin Layer Chromatography)

Solvent polarity has been related to R_f value of nitrocompounds.

100 mg p-nitrophenol and picric acid have different R_f value on silica gel plate 

∴ Preparative TLC is best to separate 100 mg of para nitrophenol and picric acid