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The rate of a certain biochemical reaction at physiological temperature (T) occurs 106 times faster with enzyme than without. The change in the activation energy upon adding enzyme is : 

(1) –6RT 

(2) +6RT 

(3) +6(2.303)RT 

(4) –6(2.303)RT

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Answer is (4) –6(2.303)RT

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Answer is (4)

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