Denaturation of Proteins:
A protein present in the biological system with a unique three-dimensional structure and biological activity is known as the native protein. When a native protein is subjected to either some physical change or chemical change by taking part in certain chemical reactions which bring about a change in pH, this leads to denaturation of the native protein. The denaturation is due to the breaking of the H-bonds as a result of which the globules unfold and helix get uncoiled. The protein loses its biological activity on account of denaturation. Chemically denaturation does not change the primary structure of the protein and only brings about change in secondary and tertiary structures.
