Question

Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.

(a) True

(b) False

The question was posed to me in examination.

I need to ask this question from Localized Alignments in Sequences topic in portion Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct option is (b) False

Explanation: These methods do not use substitution matrices such as the PAM and BLOSUM matrices to score matches. Rather, they are based on finding exact matches that have the same spacing in at least some of the input sequences, and that may be repeated in a given sequence.